ActiFolate® is our exclusive, proprietary blend of three key forms of folate: folic acid, 5-formyltetrahydrofolate, and L-5-methyltetrahydrofolate (L-5-MTHF). This combination of folates uniquely supports healthy methylation, homocysteine levels, pregnancy, mental function, and other critical functions of folate. Providing three forms of folate may better ensure optimal folate nutrition even in those with genetic variations in folate metabolism (up to 40% of the population) who may not receive the vital benefits expected from dietary or supplemental folic acid.